Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

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Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

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作者：Paola Di Meglio¹ ; ⁵ ; Joã ; o H. Duarte¹ ; ⁵ ; Helena Ahlfors¹ ; Nick D.L. Owens² ; Ying Li¹ ; Federica Villanova³ ; Isabella Tosi³ ; Keiji Hirota¹ ; ⁶ ; Frank O. Nestle³ ; Ulrich Mrowietz⁴ ; Michael J. Gilchrist² ; Brigitta Stockinger¹ ; ^{bstocki@nimr.mrc.ac.uk" class="auth_mail}
刊名：Immunity
出版年：19 June 2014
年：2014
卷：40
期：6
页码：989-1001
全文大小：3634 K

文摘

•: Physiological AhR signals reduce psoriasis gene expression in patient biopsies
•: Blocking AhR signals exacerbates psoriasis gene expression in patient biopsies
•: AhR-deficient mice show exacerbated skin inflammation in imiquimod model
•: Absence of AhR on mouse or human keratinocytes causes excessive inflammation

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