mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia

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• 作者：Christos K. Kontos^a ; ^b ; ¹ ; Sotirios G. Papageorgiou^a ; ¹ ; Marios A. Diamantopoulos^b ; Andreas Scorilas^b ; Efthimia Bazani^a ; Diamantina Vasilatou^a ; Konstantinos Gkontopoulos^a ; Eirini Glezou^a ; Georgia Stavroulaki^a ; George Dimitriadis^a ; Vasiliki Pappa^a ; ^{vas_pappa@yahoo.com}
• 关键词：ARNT ; aryl hydrocarbon receptor nuclear translocator ; BCa ; bias-corrected and accelerated ; CLL ; chronic lymphocytic leukemia ; bp ; base pair ; CI ; confidence interval ; HIF ; hypoxia-inducible factor ; HIF1A ; hypoxia inducible factor 1 regulatory α-subunit ; HR ; hazard ratio ; IGHV ; immunoglobulin heavy chain variable region ; LDH ; lactate dehydrogenase ; OS ; overall survival ; PBMC ; peripheral blood mononuclear cell ; PCR ; polymerase chain reaction ; qPCR ; quantitative real-time PCR ; RQU ; relative quantifi
• 刊名：Leukemia Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：53
• 期：Complete
• 页码：65-73
• 全文大小：1413 K
• 卷排序：53

文摘

A cost-effective qPCR method for quantification of HIF1A mRNA levels was developed. HIF1A mRNA levels do not differ between normal blood samples and leukemic B cells. High HIF1A mRNA expression predicts poor overall survival in CLL patients. Prognostic significance of HIF1A mRNA is independent of clinicopathological factors. HIF1A mRNA is an unfavorable prognosticator in distinct subgroups of CLL patients.