Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms

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Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms

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作者：Pamela J. Roqué ; ^a ; Khoi Dao^a ; Lucio G. Costa^a ; ^b ; ^{lgcosta@u.washington.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Diesel particles ; Microglia ; Neuroinflammation ; Neuronal death ; Oxidative stress
刊名：Neurotoxicology
出版年：2016
出版时间：September 2016
年：2016
卷：56
期：Complete
页码：204-214
全文大小：1560 K

文摘

•: Diesel particles are toxic to CGNs only in the presence of microglia.
•: Microglia release pro-inflammatory cytokines in response to diesel particles.
•: Blocking microglia activation protects neurons from diesel particle toxicity.

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