Combusted but not smokeless tobacco products cause DNA damage in oral cavity cells

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Combusted but not smokeless tobacco products cause DNA damage in oral cavity cells

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作者：Hong Gao^a ; G.L. Prasad^c ; Wolfgang Zacharias^a ; ^b ; ^{w0zach01@louisville.edu" class="auth_mail}
关键词：CAS ; complete artificial saliva ; CI ; cell intensity ; COPD ; chronic obstructive pulmonary disease ; DME ; Dulbecco's Modified Eagle ; DMSO ; dimethylsulfoxide ; EC ; effective concentration ; HGEC ; human gingival epithelial cells ; HGF ; human gingival fibroblasts ; I ; intensity ; NIC ; nicotine ; nTM ; normalized tail moment ; SRB ; Sulforhodamine B ; ST ; smokeless tobacco ; TL ; tail length ; TM ; tail moment ; TPM ; total particulate matter ; TPP ; tobacco product preparation
刊名：Environmental Toxicology and Pharmacology
出版年：May 2014
年：2014
卷：37
期：3
页码：1079-1089
全文大小：2706 K

文摘

•: Different human oral cavity cell phenotypes were exposed to different tobacco product preparations.
•: DNA damage was assessed by Comet assays and immunofluorescence for 纬-H2AX protein.
•: Combusted tobacco product TPM caused substantial DNA damage in oral cavity cell.
•: Non-combusted tobacco products ST/CAS or NIC exerted no or only minimal DNA damage.
•: Data support epidemiologic evidence for reduced harm of non-combusted tobacco products.

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