RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling

详细信息    查看全文

• 作者：Xueer Wang^a ; Pei Tang^a ; Fukun Guo^c ; Min Zhang^a ; Yinghua Chen^a ; Yuan Yan^a ; Zhihui Tian^a ; Pengcheng Xu^a ; Lei Zhang^a ; Lu Zhang^b ; ^{zlulu70@126.com} ; Lin Zhang^a ; ^{zlilyzh@126.com}
• 关键词：Activin B ; BMSCs ; Rho GTPase ; Cell migration
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3011-3018
• 全文大小：1418 K
• 卷排序：1861

文摘

RhoA regulates stress fiber formation and migration maybe by distinct mechanisms in BMSCs. Stress fiber formation and cell migration can be uncoupled in BMSCs. A RhoA-ROCK-LIMK2-Cofilin signaling node exists and regulates actin stress fiber formation in BMSCs. RhoA regulates Activin B-induced cell migration independent of ROCK.