Screening, verification, and analysis of biomarkers for drug-induced cardiac toxicity in vitro based on RTCA coupled with PCR Array technology

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• 作者：Lu Zhang^a ; ^b ; ¹ ; Meng-Xi Xu^b ; ¹ ; Qing-Sheng Yin^b ; Cai-Ying Zhu^a ; Xue-Lian Cheng^a ; Yi-Ran Ren^a ; Peng-Wei Zhuang^b ; ^{zhuangpengwei@163.com} ; Yan-Jun Zhang^b ; ^{zyjsunye@163.com}
• 关键词：RTCA ; Real Time Cell Analysis ; IPA ; Ingenuity Pathway Analysis ; FBS ; fetal bovine serum ; CCK8 ; Cell Counting Kit 8 ; DMEM ; Dulbecco&rsquo ; s modified eagle medium ; LDH ; lactate dehydrogenase ; DOX ; doxorubicin ; ISO ; isoprenaline ; OUA ; ouabain ; Vc ; Vitamin C ; PAR ; paracetamol ; MON ; monocrotaline ; ETI ; etimicin ; GEN ; gentamicin ; DAU ; daunorubicin ; MET ; metoprolol ; ACO ; aconitine ; RSD ; relative standard deviation
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：268
• 期：Complete
• 页码：17-25
• 全文大小：3552 K
• 卷排序：268

文摘

A high-throughput assessment of drug-induced cardiotoxicity in vitro. The common predictive genomics biomarkers of Rps6kb1 was identified and verified in several drugs. Ingenuity Pathway Analysis (IPA) was applied to combine relevant pathways of RPS6KB1 in human species.