Fucoidan inhibits LPS-induced inflammation in vitro and during the acute response in vivo

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• 作者：Jisang Park^a ; ¹ ; Jeong-Dan Cha^b ; ^c ; ¹ ; Kyung-Min Choi^c ; Kyung-Yeol Lee^b ; Kang Min Han^d ; ^{kiekie53@hanmail.net} ; Yong-Suk Jang^a ; ^e ; ^{yongsuk@jbnu.ac.kr}
• 关键词：ABC ; alveolar bone crest ; CBA ; Cytometric Bead Array ; CEJ ; cement-enamel junction ; CT ; computed tomography ; DC ; dendritic cell ; FBS ; fetal bovine serum ; H&E ; hematoxylin and eosin ; iNOS ; induced nitric oxide synthase ; LPS ; lipopolysaccharide ; MIC ; minimum inhibitory concentration ; NO ; nitric oxide ; PGE2 ; prostaglandin E2 ; pg-LPS ; P. gingivalis-LPS ; PMA ; phorbol-12-myristate 13-acetate ; RQ ; relative quantitation ; qRT-PCR ; quantitative real-time PCR ; RgpA ; Arg-gingipain B ; rRgpB ; recombinant RgpB
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：91-98
• 全文大小：1200 K
• 卷排序：43

文摘

Effects of fucoidan on bacteria-induced gingival inflammation have not been reported. We confirmed the anti-inflammatory activity of fucoidan in macrophage cell line. Fucoidan inhibited inflammation in the gingival tissue of LPS-injected mice. Fucoidan treatment did not clear P. gingivalis in the periodontitis model. We conclude that fucoidan exerts anti-inflammatory effects in vitro and in vivo.