Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China

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Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: A cross-sectional study in China

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作者：Yi-Xin Wang^a ; ^b ; Qiang Zeng^a ; ^b ; Yang Sun^e ; Ling You^a ; ^b ; Peng Wang^e ; Min Li^a ; ^b ; Pan Yang^a ; ^b ; Jin Li^a ; ^b ; Zhen Huang^a ; ^b ; Cheng Wang^d ; Shuai Li^c ; Yang Dan^c ; ¹ ; Yu-Feng Li^d ; ¹ ; Wen-Qing Lu^a ; ^b ; ¹ ; ^{luwq@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：BBzP ; butyl benzyl phthalate ; DEP ; diethyl phthalate ; DEHP ; di-(2-ethylhexyl) phthalate ; FAI ; free androgen index ; FSH ; follicle-stimulating hormone ; ICC ; intraclass correlation coefficients ; LH ; luteinizing hormone ; LOD ; the limits of detection ; MBP ; monobutyl phthalate ; MBzP ; monobenzyl phthalate ; MEP ; monoethyl phthalate ; MEHP ; mono(2-ethylhexyl) phthalate ; MEHHP ; mono(2-ethyl-5-hydroxyhexyl) phthalate ; MEOHP ; mono(2-ethyl-5-oxohexyl) phthalate ; MMP ; monomethyl phthalate ; MOP ; mono-n-octyl ph
刊名：Environmental Research
出版年：2016
出版时间：October 2016
年：2016
卷：150
期：Complete
页码：557-565
全文大小：824 K

文摘

•: 5">We measured 8 phthalate metabolites in repeated urine samples as exposure markers.
•: Associations of the markers with hormones and sperm DNA integrity were assessed.
•: 5">MEHP levels were associated with decreased serum estradiol and testosterone.
•: 20">Metabolites of DEHP were associated with sperm DNA damage and sperm apoptosis.

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