A SLM2 Feedback Pathway Controls Cortical Network Activity and Mouse Behavior

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• 作者：Ingrid Ehrmann¹ ; Matthew R. Gazzara² ; ³ ; Vittoria Pagliarini⁴ ; Caroline Dalgliesh¹ ; Mahsa Kheirollahi-Chadegani¹ ; Yaobo Xu¹ ; Eleonora Cesari⁴ ; Marina Danilenko¹ ; Marie Maclennan¹ ; Kate Lowdon¹ ; Tanja Vogel⁵ ; Piia Keskivali-Bond⁶ ; Sara Wells⁶ ; Heather Cater⁶ ; Philippe Fort⁷ ; Mauro Santibanez-Koref¹ ; Silvia Middei⁸ ; Claudio Sette⁴ ; Gavin J. Clowry⁹ ; ^{gavin.clowry@ncl.ac.uk} ; Yoseph Barash² ; ¹⁰ ; ^{yosephb@upenn.edu} ; Mark O. Cunningham⁹ ; ^{mark.cunningham@ncl.ac.uk} ; David J. Elliott¹ ; ¹¹ ; ^{david.elliott@newcastle.ac.uk}
• 关键词：RNA-seq ; alternative splicing ; gene expression ; transcriptome ; Neurexin splicing ; RNA binding proteins ; neuron ; hippocampus ; brain
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：17
• 期：12
• 页码：3269-3280
• 全文大小：3850 K
• 卷排序：17

文摘

SLM2 splicing targets are spatially controlled within the hippocampus RNA-seq reveals SLM2 feedback control and synaptic protein splicing targets Loss of SLM2 dampens patterns of hippocampal γ oscillations Loss of SLM2 changes mouse behavior that depends on these neural networks