Subtype-specific block of voltage-gated K⁺ channels by μ-conopeptides

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• 作者：Enrico Leipold^a ; Florian Ullrich^a ; ¹ ; Markus Thiele^a ; Alesia A. Tietze^b ; Heinrich Terlau^c ; Diana Imhof^d ; Stefan H. Heinemann^a ; ^{Stefan.H.Heinemann@uni-jena.de}
• 关键词：Channel block ; Pain ; Patch clamp ; Cone snails ; Conotoxin ; Neurotoxin
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1135-1140
• 全文大小：994 K
• 卷排序：482

文摘

μ-Conopeptides typically inhibit voltage-gated Na+ channels. μ-PIIA and μ-SIIIA also block KV1.2 and KV1.6 voltage-gated K+ channels. Subtype specificity is mediated by the channel's pore and turret domain. μ-Conotoxins display marked target promiscuity.