Dysregulation of PINCH signaling in mesial temporal epilepsy

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• 作者：Charles Liu^a ; Jon Russin^a ; Christianne Heck^a ; Keisuke Kawata^b ; ^c ; ^d ; Radhika Adiga^b ; William Yen^b ; Jonathan Lambert^e ; Benjamin Stear^b ; Meng Law^a ; Yvette Marquez^a ; Peter Crino^f ; David Millett^a ; Dianne Langford^b ; ^{tdl@temple.edu}
• 关键词：PINCH protein ; Hyperphosphorylated Tau ; Mesial temporal lobe epilepsy ; Hippocampal sclerosis
• 刊名：Journal of Clinical Neuroscience
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：43-52
• 全文大小：2564 K
• 卷排序：36

文摘

PINCH and hpTau are expressed in mesial temporal epilepsy. Data point to AKT/GSK3β signaling dysregulation in hpTau formation in MTLE. Dissecting the role of PINCH in MTLE will increase understanding mechanisms in MTLE.