CXCL12 impairs the acquisition and extinction of auditory fear conditioning in rats via crosstalk with GABAergic system

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CXCL12 impairs the acquisition and extinction of auditory fear conditioning in rats via crosstalk with GABAergic system

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作者：Lijuan Shi^a ; Qiang Bi^a ; Wai Li^a ; Ling Qin^a ; Pingting Yang^b ; ^{yangpingtingting@163.com" class="auth_mail" title="E-mail the corresponding author}
关键词：AMD3100 ; 1 ; 1&prime ; -[1 ; 4-Phenylenebis(methylene)]bis-1 ; 4 ; 8 ; 11-tetraazacyclotetradecane octahydrochloride ; CGP55845 ; [(2S)-3-[[(1S)-1-(3 ; 4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](phenylmethyl) phosphinic acid hydrochloride ; CXCL12 ; chemokine (C-X-C motif) ligand 12 ; CXCR4 ; C-X-C chemokine receptor type 4 ; DMSO ; Dimethyl sulfoxide ; GABA ; γ-aminobutyric acid
刊名：Pharmacology Biochemistry and Behavior
出版年：2016
出版时间：September 2016
年：2016
卷：148
期：Complete
页码：21-27
全文大小：808 K

文摘

•: This is the first study on the effects of CXCL12 toward fear-related behaviors.
•: Intra-amygdala infusion of CXCL12 impaired the rat's ability of fear learning.
•: The detrimental effects of CXCL12 were dependent on the CXCR4 receptor.
•: CXCL12/CXCR4 system in amygdala is related to GABAergic transmission.

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