Structure and pharmaceutical formulation development of a new long-acting recombinant human insulin analog studied by NMR and MS

详细信息    查看全文

• 作者：Elżbieta Bednarek^a ; Jerzy Sitkowski^a ; Wojciech Bocian^a ; Piotr Borowicz^b ; Grażyna Płucienniczak^b ; Dorota Stadnik^b ; Weronika Surmacz-Chwedoruk^b ; Beata Jaworska^a ; Lech Kozerski^a ; ^{l.kozerski@nil.gov.pl}
• 关键词：PFGSE NMR ; pulsed field gradient spin echo nuclea magnetic resonance ; ESI&ndash ; MS ; electronspray ionization mass spectrometry ; DOSY ; diffusion ordered spectroscopy
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：135
• 期：Complete
• 页码：126-132
• 全文大小：1913 K
• 卷排序：135

文摘

NMR structure of novel long acting recombinant humn insulin analog A22S-B3K-B31R established in water/acetonitrile solution Development studies on pharmaceutical formulation are presented and compared to human insulin formulation. Pharmacokinetic data are presented and compared to glargine insulin characterized by the same profile of action.