Convenient synthesis of selected meta- and ortho-substituted pentaarylpyridines via the Suzuki-Miyaura cross-coupling reaction

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• 作者：Piotr Pomarański^a ; Piotr Roszkowski^a ; Jan K. Maurin^b ; ^c ; Armand Budzianowski^c ; Zbigniew Czarnocki^a ; ^{czarnoz@chem.uw.edu.pl}
• 关键词：Atropisomerism ; Steric effects ; Palladium-catalyzed reaction ; Rotational barriers ; Nitrogen heterocycles
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：58
• 期：5
• 页码：462-465
• 全文大小：715 K
• 卷排序：58

文摘

Axially chiral compounds are important building motifs. The Suzuki-Miyaura cross-coupling reaction is an efficient method for biaryl synthesis. A simple procedure for the synthesis of pentabromopyridine allows for further transformation to polyarylated pyridines.