Although PARP1's actions have been most commonly studied in the nucleus, several lines of data demonstrate that PARP1 is also present in the mitochondria.

10">Mitochondrial PARP1 plays an important role in the regulation of various cellular functions in health and disease.

10">The current article reviews the experimental evidence for the mitochondrial localization of PARP1 and its intra-mitochondrial functions, with focus on cellular bioenergetics, mitochondrial DNA repair and mitochondrial dysfunction.

10">In addition, we also propose a working model for the interaction of mitochondrial and nuclear PARP during oxidant-induced cell death.