Association of pooled cohort risk scores with vascular inflammation and coronary artery calcification in Korean adults

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• 作者：Hye Jin Yoo^a ; ¹ ; Hwan Seok Yong^b ; ¹ ; Soon Young Hwang^c ; Jae Seon Eo^d ; Ho Cheol Hong^a ; Ji A. Seo^a ; Sin Gon Kim^a ; Nan Hee Kim^a ; Dong Seop Choi^a ; Sei Hyun Baik^a ; Kyung Mook Choi^a ; ^{medica7@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CVD ; cardiovascular disease ; FDG ; 18F-fluorodeoxyglucose ; PET ; positron emission tomography ; MDCT ; multi-detector computed tomography ; TBR ; target-to-background ratio ; FRS ; Framingham risk score ; CACS ; coronary artery calcium scores ; hsCRP ; high-sensitivity C-reactive protein ; BMI ; body mass index ; HDL-C ; high-density lipoprotein cholesterol ; HOMA-IR ; homeostasis model assessment for insulin resistance ; SUV ; standardized uptake value
• 刊名：Metabolism
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：65
• 期：3
• 页码：1-7
• 全文大小：387 K

文摘

A new pooled cohort risk equation to estimate atherosclerotic cardiovascular disease (CVD) risk was recently published, but the equation is based primarily on data from Caucasian populations. The relationship of this new risk scoring system with vascular inflammation and calcification has yet to be examined.

Methods

A total of 74 participants were retrospectively selected based on inclusion and exclusion criteria. All participants underwent ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and multi-detector computed tomography (MDCT) examination in the Korea University Guro Hospital between June 2009 and May 2013. Vascular inflammation of the carotid artery was measured as target-to-background ratio (TBR) using ¹⁸F-FDG-PET/CT and coronary artery calcification was quantified as Agatston score by MDCT.

Results

Agatston scores were not significantly associated with any metabolic risk factors, but maximum TBR values exhibited a significant positive correlation with body mass index (r = 0.31, P = 0.01), waist circumference (r = 0.42, P < 0.01), waist-to-hip ratio (r = 0.49, P < 0.01), and systolic (r = 0.35, P < 0.01) and diastolic blood pressure (r = 0.39, P < 0.01). Furthermore, maximum TBR values were significantly correlated with serum high-sensitivity C-reactive protein (hsCRP) levels (r = 0.26, P = 0.03), whereas Agatston scores had no correlation. When pooled cohort risk equation scores were divided into incremental tertiles, age, waist circumference, waist-to-hip ratio and systolic blood pressure showed significant incremental trends. In particular, pooled cohort risk scores exhibited a significant positive correlation with maximum TBR values (r = 0.35, P < 0.01), but not with Agatston scores (r = 0.11, P = 0.34).

Conclusions

The pooled cohort risk equation exhibited significant positive correlations with vascular inflammation but not with calcification in Asian subjects without CVD, suggesting that this novel risk equation may detect early inflammatory changes preceding the structural modification of vessel walls.