Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma

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Immunoproteomic studies on paediatric opsoclonus-myoclonus associated with neuroblastoma

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作者：Estefaní ; a Torres-Vega^a ; Marí ; a Durá ; n-Moreno^b ; Manuel Sá ; nchez del Pino^c ; Yania Yá ; ñ ; ez^d ; Adela Cañ ; ete^d ; Victoria Castel^d ; Rogelio Ló ; pez-Cuevas^e ; Juan Jesú ; s Ví ; lchez^a ; ^e ; Josep Dalmau^f ; ^g ; ^h ; Francesc Graus^h ; José ; Manuel Garcí ; a Verdugo^b ; Luis Bataller^a ; ^e ; ^{bataller_lui@gva.es" class="auth_mail" title="E-mail the corresponding author}
关键词：OMS ; Opsoclonus-myoclonus syndrome ; SCLC ; Small-cell lung cancer ; NMDA ; N-methyl-d aspartate ; GABA ; Gamma-aminobutyric acid ; EDTA ; Ethylenediaminetetraacetic ; PBS ; Phosphate buffer saline ; HEK ; Human embryonic kidney cells ; ELAV-like ; Embryonic lethal abnormal vision-Drosophila ; KIF21 ; Kinesin family member 21 ; Kv3.3 or 3.1 ; Shaw-potassium voltage-gated channel subfamily C member 3 or 1 ; AMPA ; Amino-3-hydroxy-5-methyl-4isoxazolepropionic acid ; LGI1 ; Leucine-rich glioma-inactivated protein 1 ; KCT
刊名：Journal of Neuroimmunology
出版年：2016
出版时间：15 August 2016
年：2016
卷：297
期：Complete
页码：98-102
全文大小：527 K

文摘

•: We aimed to identify new cell-membrane antigens in paraneoplastic opsoclonus-myoclonus.
•: Immunogold studies showed cell-membrane IgG deposits on SH-SY5Y neuroblastoma cells.
•: Systematic immunoprecipitation experiments and proteomic analyses were used.
•: Candidate antigenic pathways included Shaw family of voltage-gated potassium channels.

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