The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation

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The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation

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作者：Hong-Jen Lee¹ ; ² ; Chien-Feng Li³ ; ⁴ ; Diane Ruan¹ ; ² ; Scott Powers⁵ ; Patricia A. Thompson² ; ⁵ ; Michael A. Frohman¹ ; Chia-Hsin Chan¹ ; ² ; ⁶ ; ^{chia-hsin.chan@stonybrook.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Molecular Cell
出版年：2016
出版时间：15 September 2016
年：2016
卷：63
期：6
页码：1021-1033
全文大小：3605 K

文摘

•: K63-linked ubiquitination activates Twist and EMT
•: RNF8 activates EMT and CSC self-renewal via Twist K63-linked ubiquitination
•: RNF8 overexpression in breast cancer predicts poor disease outcomes
•: RNF8 deficiency inhibits CSC self-renewal and cancer metastasis

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