Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates promyogenic signaling pathways, thereby promoting myoblast differentiation

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Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates promyogenic signaling pathways, thereby promoting myoblast differentiation

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作者：Sang-Jin Lee^a ; Ga-Yeon Go^a ; Miran Yoo^a ; Yong Kee Kim^a ; Dong-Wan Seo^b ; Jong-Sun Kang^c ; Gyu-Un Bae^a ; ^{gbae@sookmyung.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：Akt ; Myoblast differentiation ; p38MAPK ; Promyogenic signaling ; PPARβ/δ
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：29 January 2016
年：2016
卷：470
期：1
页码：157-162
全文大小：1826 K

文摘

•: A PPARβ/δ agonist, GW0742 promotes myoblast differentiation.
•: GW0742 activates both p38MAPK and Akt activation in myogenic differentiation.
•: GW0742 enhances MyoD activity for myogenic differentiation.
•: Overexpression of PPARβ/δ enhances myoblast differentiation via activating promyogenic signaling pathways.
•: This is the first finding for agonistic mechanism of PPARβ/δ in myogenesis.

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