Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons

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Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons

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作者：G.-Q. Chang ; O. Karatayev ; O. Lukatskaya ; S.F. Leibowitz ; ^{leibow@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Prenatal fat ; Peroxisome proliferator-activated receptor (PPAR) ; β/δ ; Orexin ; Melanin-concentrating hormone ; Enkephalin ; Proliferation ; Hypothalamus ; Amygdala
刊名：Peptides
出版年：2016
出版时间：May 2016
年：2016
卷：79
期：Complete
页码：16-26
全文大小：2641 K

文摘

•: Prenatal fat exposure stimulates PPAR β/δ immunoreactive cells in offspring brain.
•: Prenatal fat increases the proliferation and density of PPAR β/δ neurons.
•: Prenatal fat stimulates co-existence of PPAR β/δ with orexigenic peptides.
•: Prenatal fat stimulates genesis and differentiation of PPAR β/δ and peptide neurons.
•: Increased of peptides neurons may stimulate consummatory behavior in offspring.

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