Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes

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Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes

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作者：Jamie K. Schnuck^a ; ^{schnuj12@highpoint.edu" class="auth_mail" title="E-mail the corresponding author} ; Kyle L. Sunderland^a ; ^{ksunderl@highpoint.edu" class="auth_mail" title="E-mail the corresponding author} ; Nicholas P. Gannon^b ; ^{ngannon@mcw.edu" class="auth_mail" title="E-mail the corresponding author} ; Matthew R. Kuennen^a ; ^{mkuennen@highpoint.edu" class="auth_mail" title="E-mail the corresponding author} ; Roger A. Vaughan^a ; ^{rvaughan@highpoint.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Mitochondrial biogenesis ; PPARα ; PPARβ/δ ; PPARγ ; PGC-1α
刊名：Biochimie
出版年：2016
出版时间：September-October 2016
年：2016
卷：128-129
期：Complete
页码：1-7
全文大小：803 K

文摘

•: Leucine induces PPARβ/δ expression and PPARβ/δ-dependent oxygen consumption.
•: Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis.
•: Increased mitochondria fuels elevated oxygen consumption independent of altered efficiency.
•: Leucine-mediated glucose uptake may promote substrate oxidation and energy storage.
•: Leucine-induced PPARγ and FAS expression increasing cellular lipid content.

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