Interaction between platelets and endothelial progenitor cells via LPA-Edg-2 axis is augmented by PPAR-δ activation

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Interaction between platelets and endothelial progenitor cells via LPA-Edg-2 axis is augmented by PPAR-δ activation

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作者：Jung-Kyu Han^a ; ^b ; Back-Kyung Kim^a ; Joo-Yun Won^a ; Youngchul Shin^a ; ^b ; Saet-Byeol Choi^a ; ^b ; Injoo Hwang^a ; ^b ; Jeehoon Kang^a ; ^b ; Ho-Jae Lee^a ; Seok-Jin Koh^a ; Jaewon Lee^a ; Jin Hur^a ; Hyun-Jai Cho^a ; ^b ; In-Ho Chae^a ; ^b ; Byung-Hee Oh^a ; ^b ; Young-Bae Park^a ; ^b ; Hyo-Soo Kim^a ; ^b ; ^c ; ^{hyosoo@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：ADRP ; Adipose differentiation-related protein ; COX ; Cyclooxygenase ; EBM ; Endothelial basal media ; EC ; Endothelial cells ; ECM ; Extracellular matrix ; Edg ; Endothelial differentiation gene ; EGM ; Endothelial growth media ; EPC ; Endothelial progenitor cells ; IGFBP-3 ; Insulin-like growth factor-1-binding protein-3 ; LPA ; Lysophosphatidic acid ; MMP-9 ; Matrix metallo-proteinase-9 ; MNCs ; Mononuclear cells ; PPAR-δ ; Peroxisome proliferator-activated receptor-δ ; PPREs ; PPAR response elements ; PSGL-1 ; P-select
刊名：Journal of Molecular and Cellular Cardiology
出版年：2016
出版时间：August 2016
年：2016
卷：97
期：Complete
页码：266-277
全文大小：3302 K

文摘

•: PPAR-δ activation in late EPCs induces vasculogenesis.
•: Edg-2 is the direct transcriptional target of PPAR-δ activation in late EPCs.
•: Platelets interact with late EPCs via LPA-Edg-2 axis.

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