PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a

详细信息    查看全文

• 作者：Juan Ji^a ; ¹ ; Xiao-Ning Zeng^b ; ¹ ; Lu-Lu Cao^a ; Ling Zhang^a ; Zhan Zhao^a ; Dan-Dan Yang^a ; Xiu-Lan Sun^a ; ^{xiulans@njmu.edu.cn}
• 关键词：PPARβ/δ ; ER stress ; Methylation ; miR181a ; GRP78
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：396-406
• 全文大小：2418 K
• 卷排序：113

文摘

PPARβ/δ is the dominant subtype expressed in the primary cultured astrocytes. PPARβ/δ activation protects against corticosterone-induced astrocyte damage. PPARβ/δ activation protects against ER stress-induced apoptosis of astrocytes. PPARβ/δ activation up-regulates miR-181a levels in astrocytes. PPARβ/δ activation inhibits Dnmts and decreases CpG island methylation of MiR-181a1.