Abnormal premotor-motor interaction in heterozygous Parkin- and Pink1 mutation carriers

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• 作者：Anne Weissbach^a ; ^b ; Tobias Bä ; umer^a ; Peter P. Pramstaller^c ; Norbert Brü ; ggemann^a ; ^b ; Vera Tadic^a ; ^b ; Robert Chen^d ; Christine Klein^a ; Alexander Mü ; nchau^a ; ^{alexander.muenchau@neuro.uni-luebeck.de}
• 关键词：AMC ; asymptomatic ; heterozygous Parkin and PINK1 mutation carriers ; AMT ; active motor thresholds ; DRD ; dopa-responsive dystonia ; EMG ; electromyography ; FDI ; first dorsal interosseus muscles ; fMRI ; functional magnetic resonance imaging ; iPD ; idiopathic Parkinsonism ; M1 ; primary motor cortex ; MEP ; motor-evoked potential ; PMd ; dorsal premotor cortex ; RMT ; resting motor thresholds ; SMA ; supplementary motor area ; TMS ; transcranial magnetic stimulation
• 刊名：Clinical Neurophysiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：128
• 期：1
• 页码：275-280
• 全文大小：324 K
• 卷排序：128

文摘

Asymptomatic heterozygous Parkin/PINK1 mutation carriers show altered premotor–motor inhibition. A single l-dopa administration could partly reverse this alteration. These mutation carriers can serve as in vivo models to study pre-symptomatic stages of Parkinsonism.