Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol

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Anxiety-like behaviors at the end of the nocturnal period in sP rats with a “history” of unpredictable, limited access to alcohol

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作者：Giancarlo Colombo^a ; ^{colomb@unica.it" class="auth_mail" title="E-mail the corresponding author} ; Carla Lobina^a ; Paola Maccioni^a ; Mauro A.M. Carai^a ; Irene Lorrai^a ; Alessandro Zaru^a ; ^b ; Andrea Contini^c ; Claudia Mugnaini^d ; Federico Corelli^d ; Gian Luigi Gessa^a ; ^b
关键词：Time schedule of alcohol drinking ; Limited and unpredictable access to alcohol ; Experimental model of binge drinking ; Anxiety-like behaviors ; Positive allosteric modulator of the GABAB receptor ; GS39783 ; Sardinian alcohol-preferring (sP) rats
刊名：Alcohol
出版年：2015
出版时间：November 2015
年：2015
卷：49
期：7
页码：707-712
全文大小：769 K

文摘

•: Alcohol drinking in sP rats is highly sensitive to time schedule of alcohol access.
•: Unpredictability of time of alcohol availability exacerbates this sensitivity.
•: We found that alcohol expectation was associated to anxiety-related behaviors.
•: Thus, sP rats might cope with this negative affective state by alcohol drinking.
•: The anxiolytic compound, GS392783, effectively reduced excessive alcohol intake.

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