Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABA<sub>B</sub> receptor

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Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABA_B receptor

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作者：Paola Maccioni^a ; Irene Lorrai^a ; Mauro A.M. Carai^b ; Antonella Riva^c ; Paolo Morazzoni^c ; Claudia Mugnaini^d ; Federico Corelli^d ; Gian Luigi Gessa^a ; Giancarlo Colombo^a ; ^{colomb@unica.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Saikosaponin A ; Bupleurum falcatum ; GABAB receptor antagonist ; SCH50911 ; Positive allosteric modulator of the GABAB receptor ; GS39783 ; Operant ; oral alcohol self-administration ; Sardinian alcohol-preferring (sP) rats
刊名：Neuroscience Letters
出版年：2016
出版时间：16 May 2016
年：2016
卷：621
期：Complete
页码：62-67
全文大小：735 K

文摘

•: Saikosaponin A is a major ingredient of the medicinal herb, Bupleurum falcatum.
•: Saikosaponin A reduced oral alcohol self-administration in alcohol-preferring rats.
•: The effect of saikosaponin A was mediated, at least in part, by the GABA_B receptor.
•: These results extend to alcohol recent literature data on morphine and cocaine.