MHCII present antigens from a variety of intracellular and extracellular sources.
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Endosomal and non-endosomal processing pathways contribute to the MHCII peptidome.
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Lymphatic fluid is a rich source of pre-processed antigens for MHCII presentation.
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Multiple processing pathways promote presentation of a broad repertoire of peptides.
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Presentation of a broad peptide repertoire might be important for tolerance.
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