Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain

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Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain

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作者：King-Hwa Ling^a ; ^b ; ^c ; ^{lkh@upm.edu.my" class="auth_mail" title="E-mail the corresponding author} ; Peter J. Brautigan^a ; Sarah Moore^a ; Rachel Fraser^a ; Pike-See Cheah^c ; ^d ; ^e ; Joy M. Raison^f ; Milena Babic^a ; Young Kyung Lee^a ; Tasman Daish^d ; Deidre M. Mattiske^g ; Jeffrey R. Mann^h ; David L. Adelson^d ; Paul Q. Thomas^d ; Christopher N. Hahn^a ; Hamish S. Scott^a ; ^b ; ^{hamish.scott@health.sa.gov.au" class="auth_mail" title="E-mail the corresponding author}
关键词：Noncoding RNA ; Small regulatory RNA ; piRNAs ; Endo-siRNAs ; Mouse brain development ; Antisense RNA ; Natural antisense transcripts
刊名：Genomics
出版年：2016
出版时间：March 2016
年：2016
卷：107
期：2-3
页码：88-99
全文大小：1845 K

文摘

•: Sox4 gene locus encodes for multiple overlapping sense and NATs.
•: Sox4 sense and NATs form dsRNA aggregates in the brain cells.
•: Sox4 sense and NATs serve as a dsRNA template for Sox4_sir3 biogenesis.
•: Sox4ot1 is required to induce Sox4_sir3 production in vitro.
•: Sox4_sir3 resembles a siRNA or piRNA small RNAs.

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