Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis

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• 作者：Kazunori Hashimoto ; Yoshiaki Tsuji ; ^{ytsuji@ncsu.edu}
• 关键词：cAMP ; cyclic AMP ; CREB ; cAMP-responsive element-binding protein ; CBP ; CREB-binding protein ; KID ; kinase-inducible domain ; ATF1 ; activating transcription factor 1 ; CRE ; cAMP-response element ; TAF4 ; transcription initiation factor TFIID subunit 4 ; PKA ; protein kinase A ; HIPK ; homeodomain-interacting protein kinase ; DYRK ; dual-specificity tyrosine-phosphorylated and regulated kinase ; wt ; wild type ; kd ; kinase dead ; CCNA1 ; cyclin-A1 ; TACR1 ; tachykinin receptor 1 ; HLR ; HeLa GAL4-luciferase reporter
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：429
• 期：1
• 页码：64-78
• 全文大小：755 K
• 卷排序：429

文摘

The mechanism of CREB activation via Ser271 phosphorylation remains uncharacterized. Arsenic stabilizes HIPK2 and HIPK1 and induces the phosphorylation of CREB at Ser271. Phosphorylation of CREB at Ser271 enhances the transcription of CREB target genes. Phosphorylation of CREB at Ser271 facilitates interaction with TAF4. The HIPK2-Ser271CREB-TAF4 axis signals in parallel with the PKA-Ser133CREB-CBP axis.