• 作者：Yi Zhang^a ; Davide Agnoletti^b ; Pierre Iaria^b ; Athanase D. Protogerou^c ; Michel E. Safar^b ; Yawei Xu^a ; Jacques Blacher^b ; ^{jacques.blacher@htd.aphp.fr}
• 关键词：Gender ; Mortality ; Cardiovascular disease ; Systolic dysfunction ; Arrhythmia
• 刊名：International Journal of Cardiology
• 出版年：2012
• 出版时间：23 February 2012
• 年：2012
• 卷：155
• 期：1
• 页码：144-148
• 全文大小：277 K

Background

Methods

We assessed cardiovascular structural and functional measurements (intima-media thickness, pulse pressure, pulse wave velocity, left atrial dimension (LAD), arrhythmia, deceleration time of transmitral early diastolic flow and left ventricular ejection fraction (LVEF)), by ultrasonography, blood pressure monitor, electrocardiography and applanation tonometry, as well as conventional cardiovascular risk factors (age, body mass index, smoke, total to high density lipoprotein (HDL) cholesterol ratio, and plasma glucose), and investigated their associations with all-cause mortality in men and women, separately, in 331 consecutive patients (87 ¡À 7 years, 74.0 % female) with a history of cardiovascular disease from the geriatric departments. After a mean follow-up of 378 days, 110 deaths were recorded.

Results

In the full adjusted models, we found that increased LAD (hazard ratio [HR] = 2.24 per 1-standard deviation [SD]; 95 % confidential interval [CI]: 1.23-4.09), reduced LVEF (HR = 0.60 per 1-SD; 95 % CI: 0.38-0.96), and increased total-to-HDL cholesterol ratio (HR = 1.99 per 1-SD; 95 % CI: 1.05-3.78) were significant predictors of all-cause mortality in men, whereas the presence of arrhythmia (HR = 2.47; 95 % CI: 1.28-4.78), increased plasma glucose (HR = 1.32 per 1-SD; 95 % CI: 1.06-1.64) and decreased body mass index (HR = 0.60 per 1-SD; 95 % CI: 0.44-0.83) could significantly predict all-cause mortality in women.

Conclusions

Even in the last stage of lifespan, risk factors for all-cause death still differ significantly in men and women with cardiovascular disease.