Surfactant effect on the physicochemical characteristics of γ-oryanol-containing solid lipid nanoparticles

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Surfactant effect on the physicochemical characteristics of γ-oryanol-containing solid lipid nanoparticles

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作者：Kullavadee Karn-orachai^a ; Siwaporn Meejoo Smith^b ; ^{siwaporn.smi@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author} ; Somsak Saesoo^c ; Alongkot Treethong^c ; Satit Puttipipatkhachorn^d ; Sirapat Pratontep^e ; Uracha Rungsardthong Ruktanonchai^c ; ^{uracha@nanotec.or.th" class="auth_mail" title="E-mail the corresponding author}
关键词：Solid lipid nanoparticles ; Surfactant ; Drug delivery ; Nanocarrier ; γ-Oryzanol
刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
出版年：2016
出版时间：5 January 2016
年：2016
卷：488
期：Complete
页码：118-128
全文大小：3168 K

文摘

•: Cationic, anionic and non-ionic surfactants were explored on Compritol based SLNs.
•: Properties of drug-loaded SLNs are influenced by the surfactant composition.
•: Mixed surfactant-SLNs show superior stability due to enhanced drug incorporation.
•: Mixed surfactant-SLNs show high cell internalization ability and low cytotoxicity.
•: Charges, bulkiness of the non-ionic surfactant and ion-pairing effects play a role.

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