FeCl₃-catalyzed tandem condensation/intramolecular nucleophilic addition/C-C bond cleavage: a concise synthesis of 2-substitued quinazolinones from 2-aminobenzamides and 1,3-diketones in aqueous media

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• 作者：Guanshuo Shen ; Haifeng Zhou ; ^{haifeng-zhou@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yuebo Sui ; Qixing Liu ; Kun Zou
• 关键词：Iron ; Quinazolinone ; 2-Aminobenzamide ; 1 ; 3-Diketone ; Green synthesis
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：3 February 2016
• 年：2016
• 卷：57
• 期：5
• 页码：587-590
• 全文大小：1745 K

文摘

A concise approach for the synthesis of 2-substituted quinazolinones using an iron-catalyzed tandem reaction of 2-aminobenzamides with acyclic or cyclic 1,3-diketones via condensation, intramolecular nucleophilic addition, C–C bond cleavage in an aqueous solution of poly(ethylene glycol) under oxidant-free conditions has been developed.