Interleukin-27 inhibits malignant behaviors of pancreatic cancer cells by targeting M2 polarized tumor associated macrophages

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Interleukin-27 inhibits malignant behaviors of pancreatic cancer cells by targeting M2 polarized tumor associated macrophages

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作者：Lutian Yao ; Mengyi Wang ; Zheyu Niu ; Qiaofei Liu ; Xiang Gao ; Li Zhou ; Quan Liao ; ^{lqpumc@126.com} ; Yupei Zhao ; ^{zhao8028@263.net}
关键词：Pancreatic cancer ; Interleukin-27 ; Tumor associated macrophages ; Gemcitabine ; Metastasis
刊名：Cytokine
出版年：2017
出版时间：January 2017
年：2017
卷：89
期：Complete
页码：194-200
全文大小：2378 K
卷排序：89

文摘

M2 polarized TAMs expressed higher level of WSX-1. IL-27 could invert the polarization of M2 phenotype TAMs. IL-27 inhibited malignant behaviors of PDAC cells via macrophages.