De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging

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• 作者：Rabia Zafar ; MD ; PhD^a ; Esther Y. Hsiao ; MD^b ; Kelly N. Botteron ; MD^c ; ^d ; Robert C. McKinstry ; MD ; PhD^e ; David H. Gutmann ; MD ; PhD^b ; ^{gutmannd@neuro.wustl.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Inherited cancer syndrome ; Astrocytoma ; Neuroimaging ; T2-hyperintensities
• 刊名：Radiology Case Reports
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：11
• 期：1
• 页码：33-35
• 全文大小：551 K

文摘

Fifteen to 20% of children with neurofibromatosis type 1 develop low-grade glial neoplasms. However, since neuroimaging is not routinely obtained until a child is clinically symptomatic, little is known about presymptomatic radiographic characteristics of gliomas in this at-risk population. Herein, we describe a child with neurofibromatosis type 1 who initially had normal brain imaging before the development of multifocal gliomas. Comparison of these serial images demonstrated that brain tumors can arise de novo in children with this cancer predisposition syndrome, further underscoring the limited prognostic value of normal baseline magnetic resonance imaging.