TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States

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TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States

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作者：Laura Batti¹ ; ⁷ ; ^{batti@embl.it" class="auth_mail" title="E-mail the corresponding author} ; Mayya Sundukova¹ ; ⁷ ; Emanuele Murana⁴ ; Sofia Pimpinella¹ ; Fernanda De Castro Reis¹ ; Francesca Pagani³ ; Hong Wang⁵ ; Eloisa Pellegrino⁴ ; Emerald Perlas¹ ; Silvia Di Angelantonio³ ; ⁴ ; Davide Ragozzino⁴ ; ⁶ ; Paul A. Heppenstall¹ ; ² ; ^{paul.heppenstall@embl.it" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：21 June 2016
年：2016
卷：15
期：12
页码：2608-2615
全文大小：3008 K

文摘

•: Microglial TMEM16F channels are required for neuropathic pain development in mice
•: TMEM16F-deficient microglia display deficits in process motility and phagocytosis
•: Deleting TMEM16F spares injury-induced loss of spinal cord GABA immunoreactivity
•: Microglial phagocytosis may contribute to neuropathic pain development

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