Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer

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• 作者：Tariq A. Bhat ; Ajay K. Chaudhary ; Sandeep Kumar ; Jordan O&rsquo ; Malley ; Joseph R. Inigo ; Rahul Kumar ; Neelu Yadav ; Dhyan Chandra ; ^{dhyan.chandra@roswellpark.org}
• 关键词：Mitochondria ; Apoptosis ; Autophagy ; Endoplasmic reticulum ; Unfolded protein response
• 刊名：Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1867
• 期：1
• 页码：58-66
• 全文大小：1080 K
• 卷排序：1867

文摘

UPRER promotes switch from pro-survival to pro-death signaling under severe stress. Mitochondria facilitate pro-death signaling initiated by UPRER. ER-mediated mitochondrial dynamics affect mitochondrial function. Deregulated UPRER-mitochondrial cross talk confers resistance to apoptosis. Promoting UPRER pro-death signaling is an intriguing strategy for cancer therapy.