Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status

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Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status

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作者：Lemonica Koumbi^a ; ^{lemonica.koumbi@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Teresa Pollicino^b ; ^{tpollicino@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Giovanni Raimondo^c ; ^{giovanni.raimondo@unime.it" class="auth_mail" title="E-mail the corresponding author} ; Dimitrios Stampoulis^d ; ^{d.stampoulis@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Salim Khakoo^e ; ^{S.I.Khakoo@soton.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Peter Karayiannis^f ; ^{karayiannis.p@unic.ac.cy" class="auth_mail" title="E-mail the corresponding author}
关键词：BCP ; basal core promoter ; CHB ; chronic HBV ; cccDNA ; covalently closed circular DNA ; DNMT ; DNA methyltransferases ; DS DNA ; double stranded DNA ; HATs ; histone acetyltransferases ; HDAC1 ; class 1 histone deacetylase ; OC DNA ; open circular DNA ; ORFs ; open reading frames ; pgRNA ; pre-genomic RNA ; SS DNA ; single stranded DNA ; TSA ; Trichostatin
刊名：Virus Research
出版年：2016
出版时间：15 July 2016
年：2016
卷：220
期：Complete
页码：150-160
全文大小：1765 K

文摘

•: Basal core promote (BCP) mutations of hepatitis B virus show low replication fitness.
•: The precore mutations have no significant effect on viral replication.
•: Viral replication capacity of mutants parallels cccDNA acetylation status.
•: cccDNA is a target for methylation and is accompanied by DNMT1 upregulation.
•: HBV mutants modulate viral replication via cccDNA epigenetic control.

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