Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

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• 作者：Danië ; l H van Raalte¹ ; ² ; ^{d.vanraalte@vumc.nl" class="auth_mail" title="E-mail the corresponding author} ; C. Bruce Verchere² ; ³
• 关键词：Glucagon-like peptide (GLP)-1 receptor agonists ; beta-cell protection ; beta-cell exhaustion ; insulin secretion ; chronic treatment
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：27
• 期：7
• 页码：442-445
• 全文大小：454 K

文摘

Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.