Vitamin D receptor agonist VS-105 directly modulates parathyroid hormone expression in human parathyroid cells and in 5/6 nephrectomized rats

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• 作者：Kaichiro Sawada^a ; J. Ruth Wu-Wong^b ; ^{ruth.wuwong@prodigy.net} ; Yung-wu Chen^b ; Jerry L. Wessale^b ; Genta Kanai^a ; Takatoshi Kakuta^a ; Masafumi Fukagawa^a
• 关键词：CaSR ; calcium-sensing receptor ; CKD ; chronic kidney disease ; NX ; nephrectomized ; PTH ; parathyroid hormone ; SHPT ; secondary hyperparathyroidism ; VDR ; vitamin D receptor ; VDRA ; vitamin D receptor activator or VDR agonist
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：48-54
• 全文大小：1140 K
• 卷排序：167

文摘

VS-105 effectively down-regulates PTH mRNA expression in human parathyroid cells. VS-105 reduces secreted PTH in human parathyroid cells. VS-105 also up-regulates VDR and CaSR in human parathyroid cells. In 5/6 NX rats, VS-105 exerts a rapid effect on reducing serum PTH.