IR and IGF-1R expression affects insulin induced proliferation and DNA damage

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• 关键词：IR ; insulin receptor ; IGF-1R ; insulin like growth factor-1 receptor ; IGF-1 ; insulin like growth factor-1 inhibitor ; PPP ; 5R ; 5aS ; 8aR ; 9R)-9-hydroxy-5 ; 8 ; 8a ; 9-tetrahydro-5-(3 ; 4 ; 5-trimethoxyphenyl)-furo [3_ ; 4_ ; 6 ; 7]-naphtho[2 ; 3-d]-1 ; 3-dioxol-6(5aH)-one)
• 刊名：Toxicology in Vitro
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：68-74
• 全文大小：643 K
• 卷排序：39

文摘

Diabetic patients have higher cancer risk in comparison with healthy individuals. Insulin and insulin glargine stimulate proliferation and induce DNA damage. IR and IGF-1R expression level affect insulin-induced proliferation and DNA damage. Hyperinsulinemia could increase cancer risk in diabetic patients.