Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation
Blood brain barrier-permeable C17-spiroepoxy steroid derivative, BNN27, specifically binds to and activates NGF receptor, TrkA.
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BNN27 differentially regulates TrkA endocytosis compared to NGF, inducing fast return of TrkA into cell membrane, potentiating the neuroprotective and neuritogenic effects of NGF.
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BNN27 effectively protects NGF-dependent sympathetic and sensory neurons from apoptosis, however is deprived of the hyperalgesic properties described for NGF.
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BNN27 may represent a lead molecule for neuroprotective and neurogenic therapeutics of neurodegenerative diseases and brain trauma.
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