Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation
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文摘

Blood brain barrier-permeable C17-spiroepoxy steroid derivative, BNN27, specifically binds to and activates NGF receptor, TrkA.

BNN27 differentially regulates TrkA endocytosis compared to NGF, inducing fast return of TrkA into cell membrane, potentiating the neuroprotective and neuritogenic effects of NGF.

BNN27 effectively protects NGF-dependent sympathetic and sensory neurons from apoptosis, however is deprived of the hyperalgesic properties described for NGF.

BNN27 may represent a lead molecule for neuroprotective and neurogenic therapeutics of neurodegenerative diseases and brain trauma.

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