Coupling of Homologous Recombination and the Checkpoint by ATR

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• 作者：Ré ; mi Buisson¹ ; Joshi Niraj² ; Amé ; lie Rodrigue² ; Chu Kwen Ho¹ ; Johannes Kreuzer¹ ; Tzeh Keong Foo³ ; Emilie J.-L. Hardy¹ ; Graham Dellaire⁴ ; Wilhelm Haas¹ ; Bing Xia³ ; Jean-Yves Masson² ; ^{jean-yves.masson@crchudequebec.ulaval.ca} ; Lee Zou¹ ; ⁵ ; ⁶ ; ^{zou.lee@mgh.harvard.edu}
• 关键词：ATR ; PALB2 ; BRCA1 ; CDK ; checkpoint ; homologous recombination
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：65
• 期：2
• 页码：336-346
• 全文大小：3014 K
• 卷排序：65

文摘

ATR acts after DNA end resection to promote HR The CDK-to-ATR switch after resection is important for efficient HR ATR promotes the BRCA1-PALB2 interaction and PALB2 localization to DSBs ATR regulates PALB2 by driving a phosphorylation switch on S59 and S64