The insecticide esfenvalerate modulates neuronal excitability in mammalian central nervous system in vitro

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• 作者：Petra Varró ; ^a ; ^{varro.petra@ttk.elte.hu} ; Melinda Ková ; cs^b ; Ildikó ; Vilá ; gi^a
• 关键词：ACSF ; artificial cerebrospinal fluid ; LTP ; long-term potentiation ; fEPSP ; field excitatory postsynaptic potential ; POPS ; population spike
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：267
• 期：Complete
• 页码：39-44
• 全文大小：1223 K
• 卷排序：267

文摘

The effect of the pyrethroid esfenvalerate was investigated on rat brain slices. Hippocampal and neocortical excitability were studied with field potential recording. In vitro application of esfenvalerate had a biphasic dose effect. Lowest applied concentration led to overexcitation and repetitive firing. Higher concentrations decreased evoked potentials and inhibited LTP.