MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

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MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

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作者：Syed Arif Abdul Rehman¹ ; ³ ; Yosua Adi Kristariyanto¹ ; ³ ; Soo-Youn Choi¹ ; ³ ; Pedro Junior Nkosi¹ ; Simone Weidlich¹ ; Karim Labib¹ ; Kay Hofmann² ; Yogesh Kulathu¹ ; ^{ykulathu@dundee.ac.uk" class="auth_mail" title="E-mail the corresponding author}
刊名：Molecular Cell
出版年：2016
出版时间：7 July 2016
年：2016
卷：63
期：1
页码：146-155
全文大小：3560 K

文摘

•: MINDY is a new family of DUBs consisting of FAM63A, FAM63B, FAM188A, and FAM188B
•: MINDY DUBs are highly selective at cleaving K48-linked polyubiquitin
•: Catalytic domain of MINDY-1 adopts a distinct fold with no homology to any known DUB
•: Human MINDY-1 trims ubiquitin chains from the distal end

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