Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major

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Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major

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作者：Rodrigo Lombrañ ; a¹ ; ³ ; Alba Á ; lvarez¹ ; ³ ; José ; Miguel Ferná ; ndez-Justel¹ ; Ricardo Almeida¹ ; Cé ; sar Poza-Carrió ; n¹ ; Fá ; bia Gomes² ; Arturo Calzada² ; José ; Marí ; a Requena¹ ; Marí ; a Gó ; mez¹ ; ^{mgomez@cbm.csic.es" class="auth_mail" title="E-mail the corresponding author}
关键词：DNA replication origins ; nucleosomes ; replication timing ; transcription ; Leishmania major ; genome-wide mapping
刊名：Cell Reports
出版年：2016
出版时间：9 August 2016
年：2016
卷：16
期：6
页码：1774-1786
全文大小：3763 K

文摘

•: L. major DNA replication origins and nucleosome occupancies are mapped at high resolution
•: Those datasets are integrated with mRNA profiling and epigenetic marks
•: Nucleosome patterns recapitulate RNA polymerase kinetics
•: DNA replication initiates at sites of RNA polymerase pausing and termination

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