The role of sex hormones and steroid receptors on female reproductive cancers

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• 作者：Luiz Gustavo de Almeida Chuffa^a ; ^{chuffa@ibb.unesp.br} ; Luiz Antonio Lupi-Jú ; nior^a ; Aline Balandis Costa^b ; Joã ; o Paulo de Arruda Amorim^c ; Fá ; bio Rodrigues Ferreira Seiva^d
• 关键词：Ovarian cancer ; Breast cancer ; Endometrial cancer ; E2 ; P4 ; ER ; PR
• 刊名：Steroids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：118
• 期：Complete
• 页码：93-108
• 全文大小：2476 K
• 卷排序：118

文摘

Changes in sex hormones and steroid receptors are associated to female reproductive cancers. E2 promotes tissue growth and increases the potential of cancer cells to metastasis. E2-ER pathway stimulates cell migration, differentiation, and survival in gynecologic tumors. The role of P4-PR signaling remains controversial in most of the gynecological malignancies. Identification of ER and PR-positive tumors can guide appropriate therapeutic planning.