Repurposing Drugs to Target the Diabetes Epidemic

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• 作者：Nigel Turner¹ ; Xiao-Yi Zeng² ; Brenna Osborne¹ ; Suzanne Rogers² ; ³ ; Ji-Ming Ye² ; ^{jiming.ye@rmit.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：diabetes ; drug discovery ; alternative strategies
• 刊名：Trends in Pharmacological Sciences
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：37
• 期：5
• 页码：379-389
• 全文大小：1828 K

文摘

Despite major investment by pharmaceutical companies in conventional drug discovery pipelines, development of new drugs has failed to keep up with the increasing incidence of many diseases, including type 2 diabetes (T2D). Drug repurposing, where existing drugs are applied to a new indication, is gaining momentum as a successful approach to overcome the bottlenecks commonly encountered with conventional approaches. Repurposing takes advantage of available information on the molecular pharmacology of clinical agents to drastically shorten drug development timelines. This review discusses recent advances in the discovery of new antidiabetic agents using repurposing strategies.