Chloroquine inhibits Rhodococcus equi replication in murine and foal alveolar macrophages by iron-starvation

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Chloroquine inhibits Rhodococcus equi replication in murine and foal alveolar macrophages by iron-starvation

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作者：Leticia T. Gressler^a ; Angela I. Bordin^b ; Cole M. McQueen^b ; Noah D. Cohen^b ; ^{NCOHEN@cvm.tamu.edu" class="auth_mail" title="E-mail the corresponding author} ; Agueda Castagna de Vargas^a ; ^{agueda.vargas@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Chloroquine ; Iron ; Macrophage ; rhbC ; Rhodococcus equi ; vapA
刊名：Veterinary Microbiology
出版年：2016
出版时间：30 May 2016
年：2016
卷：188
期：Complete
页码：16-24
全文大小：806 K

文摘

•: Chloroquine exposure reduce survival of R. equi within macrophages.
•: vapA and rhbC expression is increased in R. equi under chloroquine exposure.
•: Fe starvation is the probable action mechanism of chloroquine.

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