Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART)

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• 作者：Henry E. Wang^a ; ^{hwang@uabmc.edu" class="auth_mail" title="E-mail the corresponding author} ; David K. Prince^b ; ^{dprince@uw.edu" class="auth_mail" title="E-mail the corresponding author} ; Shannon W. Stephens^a ; ^{swstephens@uabmc.edu" class="auth_mail" title="E-mail the corresponding author} ; Heather Herren^b ; ^{hherren@uw.edu" class="auth_mail" title="E-mail the corresponding author} ; Mohamud Daya^c ; ^{dayam@ohsu.edu" class="auth_mail" title="E-mail the corresponding author} ; Neal Richmond^d ; ^{nrichmond@medstar911.org" class="auth_mail" title="E-mail the corresponding author} ; Jestin Carlson^e ; ^f ; ^{jcarlson@svhs.org" class="auth_mail" title="E-mail the corresponding author} ; Craig Warden^c ; ^{wardenc@ohsu.edu" class="auth_mail" title="E-mail the corresponding author} ; M. Riccardo Colella^g ; ^{colella@mcw.edu" class="auth_mail" title="E-mail the corresponding author} ; Ashley Brienza^f ; ^{brienzaam@upmc.edu" class="auth_mail" title="E-mail the corresponding author} ; Tom P. Aufderheide^g ; ^{taufderh@mcw.edu" class="auth_mail" title="E-mail the corresponding author} ; Ahamed H. Idris^h ; ^{aidris@sbcglobal.net" class="auth_mail" title="E-mail the corresponding author} ; Robert Schmicker^b ; ^{rschmick@uw.edu" class="auth_mail" title="E-mail the corresponding author} ; Susanne May^b ; ^{sjmay@uw.edu" class="auth_mail" title="E-mail the corresponding author} ; Graham Nichol^b ; ^{nichol@uw.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Intubation (intratracheal) ; Cardiopulmonary arrest ; Emergency medical services ; Airway management ; Resuscitation ; Clinical trials
• 刊名：Resuscitation
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：57-64
• 全文大小：735 K

文摘

Airway management is an important component of resuscitation from out-of-hospital cardiac arrest (OHCA). The optimal approach to advanced airway management is unknown. The Pragmatic Airway Resuscitation Trial (PART) will compare the effectiveness of endotracheal intubation (ETI) and Laryngeal Tube (LT) insertion upon 72-h survival in adult OHCA. Encompassing United States Emergency Medical Services agencies affiliated with the Resuscitation Outcomes Consortium (ROC), PART will use a cluster-crossover randomized design. Participating subjects will include adult, non-traumatic OHCA requiring bag-valve-mask ventilation. Trial interventions will include (1) initial airway management with ETI and (2) initial airway management with LT. The primary and secondary trial outcomes are 72-h survival and return of spontaneous circulation. Additional clinical outcomes will include airway management process and adverse events. The trial will enroll a total of 3000 subjects. Results of PART may guide the selection of advanced airway management strategies in OHCA.