MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

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MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

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作者：Dhanendra Tomar¹ ; ² ; ¹¹ ; Zhiwei Dong¹ ; ² ; ¹⁰ ; ¹¹ ; Santhanam Shanmughapriya¹ ; ² ; ¹¹ ; Diana A. Koch² ; ³ ; ¹¹ ; Toby Thomas¹ ; ² ; Nicholas E. Hoffman¹ ; ² ; Shrishiv A. Timbalia⁴ ; Samuel J. Goldman¹ ; ² ; Sarah L. Breves¹ ; ² ; Daniel P. Corbally¹ ; ² ; Neeharika Nemani¹ ; ² ; Joseph P. Fairweather¹ ; ² ; Allison R. Cutri¹ ; ² ; Xueqian Zhang² ; Jianliang Song² ; Fabiá ; n Jañ ; a¹ ; ² ; Jianhe Huang⁵ ; Carlos Barrero⁶ ; Joseph E. Rabinowitz² ; Timothy S. Luongo² ; Sarah M. Schumacher² ; Michael E. Rockman¹ ; ² ; Alexander Dietrich³ ; Salim Merali⁶ ; Jeffrey Caplan⁷ ; Peter Stathopulos⁸ ; Rexford S. Ahima⁹ ; Joseph Y. Cheung² ; Steven R. Houser⁵ ; Walter J. Koch² ; Vickas Patel⁵ ; Vishal M. Gohil⁴ ; John W. Elrod² ; Sudarsan Rajan¹ ; ² ; Muniswamy Madesh¹ ; ² ; ^{madeshm@temple.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：24 May 2016
年：2016
卷：15
期：8
页码：1673-1685
全文大小：5463 K

文摘

•: MCUR1 binds to MCU and EMRE and functions as a scaffold factor
•: The coiled-coil domains of both MCU and MCUR1 are essential for MCU complex assembly
•: Genetic deletion of MCUR1 severely impairs [Ca²⁺]_m uptake and I_MCU current
•: MCUR1 deletion impairs bioenergetics and cell migration and elicits autophagy

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